Police have close the A34 North bound, after a major collision involving FOur HGVs, a van and two cars the incident happened just after 5pm this evening.
A number of emergency are at the scene which include Police, Fire, Ambulance and Air Ambulance.
It is thought that four people have died at the scene and where all in one vehicle. There are reports of further 12 injured at the scene.
A spokeswoman for South Central Ambulance Service the service has sent out three ambulance officers Hazardous area response three ambulance crews and The Hampshire and Isle of Wight Air Ambulance .
Senior investigating officer at Thames Valley Police Insp Andy Storey said: “Officers are currently on the scene responding to this fatal collision. All motorists should avoid the area, use alternative routes and await further updates before attempting to travel on this route. We appreciate motorists’ patience while we deal with this incident.
“I would like to appeal to anyone who witnessed the collision, including anyone travelling on the southbound carriageway who saw anything they believe is significant, to contact police.”
“Anyone who has any information which could assist the investigation should call the 24-hour Thames Valley Police enquiry centre on 101 quoting URN 1109 10/8.”