Three lanes are blocked on the busy M3 Motorway and long queues have developed on the Berkshire Surrey border.
All three emergency services are at the scene.
Surrey Fire and Rescue sent three appliances from Camberley and Woking, and had to free a person trapped in a vehicle.
The crash has happened on the northbound carriageway near junction 12 of the M25 and involves three lorries.
Traffic is back to junction 3 at Bagshot.