Police were called at approximately 1.35pm on Monday, 21 March to reports of a van in collision with an e-scooter in Green Street, E13.
Officers and London Ambulance Service attended.
The rider of the e-scooter, a girl believed aged 14, was treated at the scene but died from her injuries.
Next of kin have been informed.
The driver of the van is with police – he has not been arrested.
Road closures remain in place.
Enquiries into the circumstances continue.
Anyone with information is asked to contact 101 or tweet @MetCC and quote CAD3212/21Mar.