Emergency services were called at around 8:45am to the report of a two-vehicle collision.
The collision involved a HGV and a Nissan Duke.
The driver of the Nissan a 44-year-old man was taken to Preston Royal hospital with serious injuries.
The passengers in the vehicle, a 40-year-old woman was taken Preston Royal Hospital with serious injuries, a 15-year-old boy was taken to Alder Hay Hospital via air ambulance with serious injuries and a 13-year-old boy was taken to Manchester hospital via Air ambulance with serious injuries
The driver of the HGV a 28-year-old man from Lancaster was uninjured. He was arrested in connection with the collision.
Anyone with information relating to this incident can report online at https://orlo.uk/I3ZVi , quoting incident number 36 of 16th August 2021. You can also phone on 101.
Alternatively, you can contact Crimestoppers, anonymously, on 0800 555 111.