The A2 Gravesend in Kent is set to remain closed for several hours following a fatal collision.
Despite best efforts of Paramedic at the scene of the collision a man was declared dead at the scene.
Officers were called to the scene just after 1.30am on Tuesday morning.
A closure has been put in place and will remain during the early morning rush hour to assist with collision investigation work by specialists officers.
A spokesman for Highways England said:
The A2 in Kent is closed westbound between the M2/A289 (Singlewell, Marling Cross) and the A227 (Gravesend) due to a serious Kent Police led collision. The road is expected to remain closed for several further hours.