Ten fire engines and around 70 firefighters tackled a fire in a range of garages on Balmoral Drive in Hayes.
Twenty tonnes of rubbish and a caravan are also alight.
Station Manager Mark Jordan, who was at the scene said:
“Firefighters worked extremely hard to bring the very visible blaze under control.”
The Brigade was called at 9.45pm and the fire was under control by 1.30am.
Fire crews from Hillingdon and surrounding areas were at the scene.
The cause of the fire is under investigation.