Officers from Hampshire Constabulary are dealing with a serious collision on the A33 near Micheldever.
The two-vehicle collision is on the A33 southbound at Micheldever.
Hampshire fire and rescue along with Paramedics have been called to the incident near to the junction with Larkwhistle Farm Road and the A33.
Police have advised that the closure will be in place for sometime.
Officers are advising drivers to avoid and seek alternative routes.