Police were called to Sevenoaks Road in Orpington at 10.12pm on Thursday, 31 October following a report of a road traffic collision.
Officers, London Fire Brigade and London Ambulance Service all attended.
One person, no further details, was pronounced dead at the scene.
Paramedics are also treating a number of casualties (no further details at this time).
Road closures are in place and drivers will need to find alternative routes.