Officers were called at 9.20pm on Friday, 23 October to Westbury Road, E17 after a 17-year-old boy was found suffering from a stab injury.
He was treated by paramedics at the scene but despite their best efforts, he was pronounced dead.
Officers are working to establish the male’s identity and inform his next of kin.
At this very early stage there have been no arrests.
A crime scene is in place and an investigation is in progress, led by detectives from the Met’s Specialist Crime Command (Homicide).
At this early stage, there have been no arrests.
Any witnesses or those with information are asked to call 101 or tweet @MetCC quoting 8357/23Oct.