Most of a five-roomed flat on the third floor of the building is alight.
Station Commander James Ryan is at the scene, he said: “The A2 New Cross Road, from the junction of Lewisham Way to New Cross Gate railway station, was closed and has now reopened but due to the disruption caused motorists are advised to avoid the area at this time.”
The cause of the fire is not known at this time one resident has claimed that the cause was due to a meth lab that was being kept in one of the rooms within the property. Police have arrested one man and he was taken away in a van covered with a silver sheet.
The Met Police have been approached for comment
More to follow