Police were called at 4.31pm on Sunday, 22 August following reports of a stabbing in a property on Lea Bridge Road, E10.
Officers attended with London Ambulance Service paramedics and the London Air Ambulance.
They found a 32-year-old man with life-threatening injuries.
He was treated at the scene before being transported to an east London hospital. He was pronounced dead shortly after arriving.
His next of kin are yet to be informed.
An investigation is underway but at this early stage there have been no arrests.
Anyone with information about the incident, who has not already spoken to officers, should call 101, giving the reference 4806/22AUG.
Information can also be provided to Crimestoppers, anonymously, on 0800 555 111.
No piece of information about knife crime is insignificant or too small. Any information you give to Crimestoppers can make a difference in reducing knife crime and the harm it causes to families.
Crimestoppers never ask your name and they cannot trace your call, your IP address or the device you use. Fill in their quick online form or call 0800 555 111. It could save a life.