Shops and homes have been evacuated after a 60m crane overbalanced and came to rest against the former Primark building in Reading town centre.
Thames Valley Police said officers were called to the scene in West Street just before 2pm on Saturday afternoon.
A police spokesman said people were evacuated to ensure their safety, but no-one had been reported injured.
Pedestrians and motorists are being advised to avoid the area and buses have been diverted.
Fire and ambulance crews are also at the scene.
The road remains closed and local buses are on divert.
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