Nakita Zaicevs, 12, is described as white, 4ft 10 in tall, of slim build and has short brown hair.
When last seen, he was wearing a black Adidas t-shirt with a green Adidas logo on the front and black Adidas shorts with a green Adidas logo.
Nakita has been diagnosed with ADHD which he requires medication for.
He is known to frequent Newham, Stratford areas including Westfield Shopping Centre.
Officers are becoming increasingly concerned for his wellbeing and would urge anyone with information on his whereabouts to call police on 101 or Missing People on 11600