Ten fire engines and 72 firefighters and officers were called to a roof fire at a shop with flats above in Peckham High Street, Peckham.
The roof of the building was destroyed by fire.
The Brigade was called just before 6am and the fire was under control at 9pm. Fire crews from Peckham, New Cross, Old Kent Road, Brixton and other surrounding fire stations attended the scene.
The cause of the fire is under investigation.