Emergency services are responding after a person was struck by a train near Coppermill Junction on Coppermill Lane, Walthamstow, after 7am the alarm was raised.
Commuters in the area have been advised to expect delays and disruption to services, and to seek alternative routes if possible.
Emergency crews are working at the scene, and a cordon is in place while the incident is being dealt with.
Further updates will be provided as more information becomes available.