At 7.46pm on Tuesday, 14 December police were called to reports of a stabbing in Hampton Street, SE1.
Officers attended with medics from the London Ambulance Service and London Air Ambulance.
Despite the best efforts of the emergency services, a 23-year-old man was pronounced dead at the scene.
His next of kin have been informed and an investigation is under way.
Anyone who witnessed the incident, or who has information about what took place, should call 101 giving the reference 6908/14DEC.
Information can also be provided to Crimestoppers, anonymously, on 0800 555 111.
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