Antidepressants Fail to Tackle Chronic Pain, Shocking New Review Finds
Only One Drug Offers Short-Term Relief
A major review analysed 176 trials covering nearly 30,000 patients. Most studies tracked patients’ experiences for just a few months. Among the antidepressants tested—popular ones like Prozac and cheap amitriptyline—only duloxetine showed any sign of easing pain, and that was just for the short term.
NHS Urges Caution but Supports Some Use
Despite the weak evidence, patients are advised not to stop their medication abruptly and should always consult a doctor first. NHS guidelines still back antidepressants for certain chronic pain conditions like nerve pain and fibromyalgia—preferring them over addictive opioids. Regular painkillers like paracetamol and ibuprofen aren’t recommended for these cases.
Chronic Pain Hits One in Four Brits
Chronic pain, defined as lasting longer than three months, affects one-quarter of the UK population. Causes range from arthritis to unknown origins. Experts believe antidepressants may offer relief since brain pathways for mood and pain overlap. But the proof is lacking.
Experts Raise Alarms on Lack of Long-Term Data
“The lack of long-term safety and effectiveness data is shocking,” said Prof Tamar Pincus, lead author of the review. “This is a global health concern – patients are prescribed meds without solid proof or understanding of long-term impacts.”
Dr Cathy Stannard, clinical lead for NICE chronic-pain guidelines, added that medicines for long-term pain have shown disappointing results. She highlighted the value of support services beyond healthcare, such as help with mobility, debt management, trauma, and tackling social isolation. Tailoring support to what matters most to individuals could be the best way forward.
Safe Withdrawal Is Key
The NHS warns that when stopping antidepressants, dosage must be tapered slowly over weeks to avoid withdrawal symptoms. Sudden stops can cause serious problems.
