Jojo Johnstone, 15, was last seen leaving his home in Witherwack at around 5pm on Tuesday.
Officers are now growing increasingly concerned for his welfare and are appealing to the public for help.
Jojo is described as being 5ft 7in in height, slim build, with short black hair and was last seen wearing a black tracksuit and dark blue trainers.
Anyone who has seen JoJo is asked to contact Police on 101, quoting reference M005431/22.
