Officers had issued a public appeal following the firearms incident in London Fields last month, while British Transport Police (BTP) investigate the stabbing at Hackney Central Station on 1 March.
Working with BTP colleagues, at 7.47pm on Friday, 3 March, specialist firearms officers conducted a planned stop on a vehicle using tactical contact in Essex Road N1.
Five males aged between 16 and 19 were arrested on suspicion of attempted murder and possession of a firearm with intent to endanger life and taken into custody.
There were no reported injuries.
Road closures are in place and enquiries are ongoing.
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