Orhan Ekren, 48, was last seen in the vicinity of Camden Market, near Camden Lock, at approximately 10.40pm on Tuesday, 26 November.
He was wearing dark clothing and carrying a dark backpack, which was found near the canal the following day.
Orhan is of Turkish heritage and lives with his family in Milton Keynes.
Police are particularly keen to speak to people that live in the Camden area, or who might have been in the area at the time, or that have a barge moored on the canal.
Anyone who may have seen Orhan or who has information about his whereabouts is urged to please call 101 quoting 5132/27NOV or reference 01/1137478/24.
