The incident happened on the slip road from the A500 at the Etruria Valley Junction at just after 3.30pm on Thursday afternoon.
Two ambulances, two paramedic officers, a Midlands Air Ambulance Critical Care Car and a North Staffs BASICS Emergency Doctor were sent to the scene.
A West Midlands Ambulance Service spokesman said: “We took two patients to Royal Stoke University Hospital from the car that was on it’s side. An elderly man was taken on blue lights, while a woman received less serious injuries.
A middle-aged man from the car on it’s roof was assessed by ambulance staff and was subsequently discharged at the scene.
A fourth patient, a member of the public who had gone to help those injured in the crash suffered a minor injury whilst doing so. He was treated and discharged.
The ambulance staff did not assess anyone from the third car.
